439 Macrocystis pyrifera kelp ferment affects several factors for skin barrier function

The skin's primary function is to act as a protective barrier between the organism and its external environment. Physically, it protects from threats such chemicals, allergens, irritants. Internally, skin helps maintain homeostasis enhanced loss of water. lipid matrix in stratum corneum crucial for function. proper formation can be adversely affected by deficiency lipids. Also, presence appropriate processing filaggrin are Evidence several scientific reports has shown that damage not only result water but also induce inflammatory mediators which accelerate irritation, aging, prematurely diminishing youthfulness. Our ex vivo studies showed Macrocystis pyrifera ferment we have developed was found increase level neutral lipids human model. Normal Human Epidermal Keratinocytes. Lastly, strength integrity were measured TEER (trans-epidermal electrical resistance), measurement physiological state generated ion concentration gradient. treatment wounded models with increased TEER, indicating decrease permeability an function, followed content these same models. Together, results indicate acts enhance overall